• 王 珂

• 所属流动站

  畜牧学

• 合作导师

  牟春燕 教授、崔旻 教授

• 电子邮箱

  wangke@mail.hzau.edu.cn

教育经历

2013.9-2019.6 开云手机在线登录入口（中国）有限公司动科动医学院 博士学位
2010.9-2014.6 开云手机在线登录入口（中国）有限公司生命科学技术学院 学士学位

工作经历

2019.7-至今 开云手机在线登录入口（中国）有限公司动科动医学院 博士后

研究领域

主要研究领域为嗜神经病毒感染诱导血脑屏障破坏的机制及其免疫反应。主要利用日本乙型脑炎病毒（Japanese encephalitis virus, JEV）感染小鼠为模型，探究JEV感染和入侵血脑屏障的具体过程，以及血脑屏障的破坏机制；探讨狂犬病毒（Rabies virus, RV）感染过程中G蛋白对病毒致病性的影响；病毒感染逃逸适应性免疫应答的机制研究。

科研成果

1.Wang K, Wang H, Lou W, Ma L, Li Y, Zhang N, Wang C, Li F, Awais M, Cao S, She R, Fu ZF and Cui M*. 2018. IP-10 Promotes Blood–Brain Barrier Damage by Inducing Tumor Necrosis Factor Alpha Production in Japanese Encephalitis. Front. Immunol. 9:1148. doi: 10.3389/fimmu.2018.01148.
2.Awais M, Wang K, Lin X, Qian W, Zhang N, Wang C, Wang K, Zhao L, Fu ZF, Cui M*. 2017. TLR7 Deficiency Leads to TLR8 Compensative Regulation of Immune Response against JEV in Mice. Front. Immunol. 8:160. doi: 10.3389/fimmu.2017.00160.
3.Li F#, Wang Y#, Yu L#, Cao S, Wang K, Yuan J, Wang C, Wang K, Cui M*, Fu ZF. 2015. Viral infection of the central nervous system and neuroinflammation precede blood-brain barrier disruption during Japanese encephalitis virus infection. J Virol. 89:5602–5614. doi: 10.1128/JVI.00143-15.
4.Zhang Q, Hu S, Wang K, Cui M, Li X, Wang M, Hu X*. 2018. Engineering a yeast double-molecule carrier for drug screening. Artif Cells Nanomed Biotechnol. 46:sup2. 386-396. doi: 10.1080/21691401.2018.1457539.
5.Wang C, Zhang N, Yu L, Qi L, Yuan J, Wang K, Wang K, Ma S, Wang H, Lou W, Hu P, Awais M, Cao S, Fu ZF, Cui M*. 2017. Myeloid-Derived Suppressor Cells Inhibit T Follicular Helper Cell Immune Response in Japanese Encephalitis Virus Infection. J Immunol. 199:3094–3105. doi: 10.4049/jimmunol.1700671.
6.Tian B, Zhou M, Yang Y, Yu L, Luo Z, Tian D, Wang K, Cui M, Chen H, Fu ZF* and Zhao L*. 2018. Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway. Front. Immunol. 8:2011. doi: 10.3389/fimmu.2017.02011.
7.Tang J, Zheng X, Xiao K, Wang K, Wang J, Wang Y, Wang K, Wang W, Lu S, Yang K, Sun P, Khaliq H, Zhong J, Peng K*. Effect of Boric Acid Supplementation on the Expression of BDNF in African Ostrich Chick Brain. Biol Trace Elem Res. 2016. 170: 208. doi: 10.1007/s12011-015-0428-y.

科研项目

主要奖励